중국의 Sinopharm이 개발 한 Omicron 기반 백신 후보는 3-4 개월 안에 임상 시험을 완료 할 것으로 예상됩니다., 회사의 고위 경영진은 최근에 말했다, 또한 성공적으로 개발되면 대부분의 제조 용량을 업그레이드 된 백신으로 전환 할 것이라고 덧붙입니다..
중국 국가 생명 공학 그룹, Sinopharm의 자회사, was granted permission to conduct human trials of its experimental vaccine against Omicron in Hong Kong on April 13 and received approval for trials on the mainland on April 26.
The new vaccine was first administered on Sunday to a volunteer in Hangzhou, Zhejiang province, according to the company.
Zhang Yuntao, vice-president of China National Biotech Group and its chief scientist, said that clinical trials will involve fully vaccinated people and those who have already received a third, booster shot. They will be given one or two doses of the new vaccine three to six months after the last shot.
그 동안에, the company has also started testing the upgraded vaccine in unvaccinated people, he said in an interview in late April.
The race to tailor vaccines to tackle Omicron started after scientists discovered that the variant’s biology differs notably from the original virus, which global vaccines are based on.
Although previous studies have shown that existing vaccines are still highly effective at preventing severe Omicron cases and related deaths, they are less capable of preventing infections.
Zhang said that during preclinical studies, animals vaccinated with Omicron-specific doses can generate a high level of neutralizing antibodies against the variant. The vaccine also boosted protection against the original strain and other mutations, including the Beta and Delta strains.
By comparison, animals vaccinated with the original vaccine have some neutralizing antibodies against Omicron, but their potency dropped to about one-fifth of that of antibodies against the original strain.
“The core data we will be keeping a close eye on during human trials is whether the new dose can elicit specific neutralizing antibodies against Omicron,” 그는 말했다.
As subvariants of Omicron and its recombinant versions with other variants continue to emerge, Zhang said available animal studies have shown that the new vaccine is also effective against them.
Yang Huichuan, another vice-president at China National Biotech Group, said the manufacturing techniques of the new vaccine and related quality assessment methods are in line with those of the original vaccine.
“We’re fully prepared and have sufficient raw materials and consumables for production,” 그는 말했다.
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